Native Human Complement Factor H Protein(Cat#: CTP-458)
This product is a Human factor H protein which is purified from normal human serum. It is an essential regulatory component of the alternative pathway of complement. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
Factor H |
| Molecule Mass |
155 kDa |
| Purity |
>95% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM Sodium phosphate, 145 mM NaCl, pH 7.3 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
| Alternative Names |
Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor (Complement); Beta-1H; FHL1 ; Adrenomedullin Binding Protein; Beta-1-H-Globulin; H Factor; Factor H; CFH; FH |
| Gene ID |
3075 |
| UniProt ID |
P08603 |
Customer Review
An invaluable addition to our immunology research
Excellent
It is highly pure and biologically active, ensuring reliable results in our functional assays. The protein's stability over extended periods has greatly reduced our experimental variability. Additionally, the documentation and technical support provided were top-notch, facilitating a smooth integration into our workflow.
Greatly enhanced our complement pathway studies
Excellent
I've used various complement proteins in my assays, but this product stands out for its exceptional quality. The activity level is consistently high, and the protein is free from contaminants that could interfere with my results. The reproducibility of my experiments has improved significantly since switching to this product, and the data obtained are robust and dependable.
A reliable and high-quality product
Excellent
The protein's activity remains stable even after multiple freeze-thaw cycles, which is crucial for our long-term projects. Its high purity ensures that our assays are not compromised by unwanted interactions.
We are very satisfied with this product and the support provided
Excellent
We have been using this complement factor H protein for several months, and it has consistently performed well. The protein is highly pure and active, which has ensured the reliability of our functional assays. The product is also very stable, which is crucial for our long-term projects.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
